Endocrine Abstracts

Ghrelin is a peptide hormone secreted by the stomach with orexigenic properties that induce food intake trough the activation of hypothalamic AMP activated kinase (AMPK). In rodents fed on normal diet the central administration of ghrelin induces an increase in food intake, however, when fed a high fat diet (HFD) rodents are resistant to the orexigenic effect of ghrelin. Recent data show that Cidea interacts with AMPK β-subunit and promotes AMPK degradation trough ubiquit...

Adipose tissue is a highly active metabolic organ which, together with its role as an energy storage depot, produces a wide variety of bioactive molecules (i.e. adipokines) with important roles in the regulation of energy metabolism and homeostasis, immunity and inflammation. Alterations in lipid metabolism and/or in adipokine production associated to the excess of adipose tissue that defines obesity or to adipose tissue deficiency, as occurs in lipodystrophy, are linked to in...

Current evidence suggests that the adipocyte-derived hormone resistin (RSTN) regulates both feeding and peripheral metabolism through unclear hypothalamic-mediated mechanisms. Here, we demonstrate by the first time, that the anorectic effect of RSTN is associated to specific changes in the expression of neuropeptides in the arcuate nucleus of the hypothalamus (ARC), namely AgRP, NPY and CART. Very interestingly, RSTN also exerts a deep, nutritional-dependent inhibitory effect ...

Objective: To report a rare case of papillary thyroid carcinoma (PTC) in a thyroglossal duct cyst (TGDC).Case report: A 34-year-old peruvian male came to our hospital with a complaint of a swelling cervical mass in the anterior central side of the neck, which was growing since 6 months earlier. The patient had no significant past medical, surgical history and was completely asymptomatic. He denied any family history of thyroid disease or history of head ...